This tumor more frequently affects adults in the age range of 2060 years, with a peak incidence in the 5th decade of life. Maxillary calcifying epithelial odontogenic pindborg tumor. In a sequence of interactive processes, these cells develop into enamelforming ameloblasts and dentineproducing odontoblasts. Odontogenic tumors are both benign and malignant and have been classified accordingly by who in 1992 which was further divided into sub divisions by white dk in 2004. Further treatment involved radical surgery and adjuvant radiotherapy. Calcifying epithelial odontogenic tumor, pindborg tumor, ceot introduction the calcifying epithelial odontogenic tumor ceot, also known as the pindborg tumor, is an uncommon lesion that accounts for pindborg tumor are described. University hospital, and department of histology, the royal dental college, copenhagen, denmark. The calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, is an odontogenic tumor first recognized by the danish pathologist jens jorgen pindborg in 1955. Classification, histopathology, and clinical behavior in man and domesticated animals, cancer on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Also called pindborg tumor rare ages 30 49 years may also occur within gingiva peripheral tumor may be invasive and recur locally, but less aggressive than ameloblastoma. The histological features, histogenesis, and suggested treatment were discussed in their report at that time.
Chapter 1 introducton histopathology definition it is a branch of pathology which deals with the study of disease in a tissue section. Calcifying epithelial odontogenic tumor ceot is a rare benign odontogenic tumor that was first described by pindborg in 1955. Calcifying epithelial odontogenic tumor of the maxilla. Odontogenic tumours are derived from these toothforming tissues, either the epithelial or the ectomesenchymal or both. Most tumors are located in the premolar or molar region of the mandible and are associated with the crown of an impacted tooth, 2.
Calcifying epithelial odontogenic tumor ceot, also known as pindborg tumor, is a rare, benign but locally aggressive odontogenic tumor, described for the first time by pindborg in 1955 1. Radiologic and pathologic characteristics of benign and. The calcifying epithelial odontogenic tumor ceot was first described. Calcifying epithelial odontogenic tumor pindborg tumor is a rare, benign odontogenic lesion that accounts for less than 1% of all odontogenic tumors. Calcifying epithelial odontogenic tumor ceot, or the pindborg tumor. The diagnosis is based on the histological examination revealing areas of polyhedral neoplastic cells, amyloid, and calcified deposits. Jan 24, 2004 a male patient presented with an extraordinarily large calcifying epithelial odontogenic tumor ceot or pindborg tumor that affected the maxilla. Calcifying epithelial odontogenic tumor pindborg tumor. The disease became evident due to alterations in the facial aspect, in particular of the perioral region, caused by the expanding tumor. Histopathology is the gold standard for diagnosis of ceot. The histopathological features suggested diagnosis of. To achieve this it is important that the tissue must be prepared in such a manner. Departments of dentistry and head and neck surgery.
Clinical, radiological and histological features of. Historically, histopathology and cytopathology have been the main tools utilised in the diagnosis of cancer. Teeth develop from oral cavity lining epithelial cells and cranial neural crestderived ectomesenchymal cells. Odontogenic tumoursan update diagnostic histopathology. Histopathology showed islands and cords of polyhedral odontogenic epithelial cells. Since calcifications were missing in the present case, it is considered to be a variant of the pindborg tumor. The ceot, since its description by pindborg in 1958 as a separate pathologic entity, is commonly known as the pindborg tumor. Department of pathology, boston university, boston medical center, boston, ma, usa. Histopathology techniques histopathology definition.
Calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, previously has been called adenoid adamintoblastoma, unusual ameloblastoma and cystic odontoma is typically located in the premolar and molar region of the mandible, although up to a third are found in the maxilla. Module introduction to histopathology histology and cytology 2 notes once the diagnosis is made, the slides come back to the laboratory. Global journal of oral science, 2017, 3 3336 33 pindborg. Calcifying epithelial odontogenic pindborg tumor with malignant. Since pindborg first described calcifying epithelial odontogenic tumor ceot as an entity in 1955, attempts have been made to understand the nature of the amyloidlike material present in this tumor and to find its origin. Calcifying epithelial odontogenic tumor pindborg tumor without.
Pdf calcifying epithelial odontogenic tumor ceot, also known as pindborg. The etiology of this tumor remains an enigma to the clinician. Characteristic features on histology are polygonal epithelial cells, calcification, and eosinophilic. Calcifying epithelial odontogenic tumor pindborg tumor ncbi. Although the features of the hyaline deposits did not fulfill all the. The ceot is a benign odontogenic tumor of epithelial origin that accounts for approximately 1% of all odontogenic tumors and characteristically contains. The third case of the same previous combination has been reported in 19868. A calcifying epithelial odontogenic tumor pindborg. Pindborg tumor caliaperoumal sk, gowri s, dinakar j contemp. The calcifying epithelial odontogenic tumor pindborg tumor. The calcifying epithelial odontogenic tumor is a rare benign odontogenic tumor that was first described by pindborg in 1955. The eponym pindborg tumor was first introduced to the literature in 1967 to describe this interesting and unique odontogenic tumor 3,4. The major advantages of histopathology are speed, low cost and the ability to provide a presumptive identification of the infecting fungus as well as demonstrating the tissue reaction.
Pindborg tumor or ceot is a locally aggressive neoplasm that accounts for 1% of the total odontogenic tumors, with recurrence in 14% of cases. The calcifying epithelial odontogenic tumor ceot is a rare entity and represents less than 1% of all odontogenic tumors. It is a branch of pathology which deals with the study of disease in a tissue section. Due to its deceptive appearance, it can often mislead the pathologists. In view of its low frequency and the importance of histology for its correct diagnosis and treatment as it can be confused with other benign tumors, appropriate resection is necessary with tumor free margins in order to reduce the probability of local recurrence. Pindborg tumor involving maxillary sinus and ethmoid plate global journal of oral science, 2017, vol. Verkalkender epithelialer odontogener tumor des oberkiefers.
Calcifying epithelial odontogenic pindborg tumor in a child. Original article, case study by ear, nose and throat journal. Apr 05, 2016 pindborgs tumour definition who the calcifying epithelial odontogenic tumour ceot is a locally invasive epithelial odontogenic neoplasm, characterized by the presence of amyloid material that may become calcified. Jul 02, 2001 after initial excision, this tumor recurred twice, with the recurrences exhibiting a progression to a malignant pindborg tumor odontogenic carcinoma with vascular invasion and spread to a cervical lymph node.
Pdf calcifying epithelial odontogenic tumor ceot, also known as pindborg tumor, is a rare odontogenic epithelial neoplasm. Pindborg suggested that the tumor arises from the remnants of reduced enamel epithelium of an unerupted tooth. The amyloid deposit in calcifying epithelial odontogenic. Calcifying epithelial odontogenic tumors ceot are uncommon, accounting for less than 1% of all odontogenic tumors. Pdf the calcifying epithelial odontogenic tumor is a benign epithelial tumor with characteristic clinical and histopathologic features. It can present different histological characteristics, possibly related to the length of time in the tissue and its location. An incisional biopsy from the region involved was sent for histopathological examination. Epithelioid strandsnestssheets amyloid and calcification rare clear cell variant calcifying epithelial odontogenic tumor showing nuclear atypia, amyloid, and calcification. This is a rare benign odontogenic tumor which was first described in 1955 by dutch pathologist dr j j pindborg.
Slides are filed for future reference or teachingresearch for at least. Benign odontogenic tumors are divided into three types based on the presence absense of odontogenic epithelium or ectomesenchyme. Calcifying epithelial odontogenic pindborg tumor with. This lesion is a locally aggressive benign odontogenic neoplasm arising from epithelial tissue. Calcifying epithelial odontogenic tumor radiology reference. Oct 12, 2009 calcifying epithelial odontogenic tumor pindborg tumor, is a rare benign odontogenic neoplasm representing about 0. It accounts for less than 1% of all odontogenic neoplasms. Histopathology findings revealed a neoplasm composed of cells. Odontogenic tumors by romeo papa linkedin slideshare. Since then, it is eponymously referred to as pindborg tumor and accounts to around 1% of all the odontogenic tumors.
Pdf calcifying epithelial odontogenic tumor pindborg tumor. Pdf calcifying epithelial odontogenic tumor pindborg. Odontogenic tumours are rare lesions and many nonspecialist histopathologists will not have seen many during their working lifetime. It was previously described as an adenoid adamantoblastoma, unusual ameloblastoma and a cystic odontoma. Health, general diseases health aspects relapse maxilla recurrence disease tumors care and treatment diagnosis patient outcomes. The tumor is characterized histologically by the presence of polygonal epithelial cells, calcification, and eosinophilic deposits resembling amyloid. Calcifying epithelial odontogenic tumor ceot is an extremely rare benign odontogenic tumor. After the reports are sent to the surgeons either as soft copy or hard copy, the laboratory has to perform the following functions 1. Also called true cementoma, benign osteoblastoma men and women less than 25 years old benign, may stop growing as a heavily calcified jaw nodule, may recur if excised. I have highlighted 8 important features of this unique lesion. Calcifying epithelial odontogenic tumor of the maxilla pindborg. The tumor typically appears radiolucent with scattered calcified components.
The clinical, radiographic, and histopathologic features are discussed with. Pathology outlines benign tumors tumorlike conditions. Calcifying epithelial odontogenic tumor an overview. A calcifying epithelial odontogenic tumor ceot is a locally invasive epithelial neoplasm characterized by the development of intraepithelial structures, probably of an amyloidlike nature, which may become calcified and liberated as the cells break down. Histopathology remains one of the major tools of diagnosis in mycology20 table 3. Nov 01, 2006 calcifying epithelial odontogenic tumor pindborg tumor is composed of epithelial cells in a fibrous stroma. Clinical, radiographical and histopathological evaluation 37 pindborg tumor. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis.
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